| Title |
How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale
|
|---|---|
| Published in |
Cell Biology and Toxicology, March 2013
|
| DOI | 10.1007/s10565-013-9239-0 |
| Pubmed ID | |
| Authors |
Sungwon Han, Joseph Lemire, Varun P. Appanna, Christopher Auger, Zachary Castonguay, Vasu D. Appanna |
| Abstract |
Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of α-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 27% |
| Spain | 1 | 7% |
| Canada | 1 | 7% |
| Ireland | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
| Scientists | 1 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 16% |
| Student > Master | 13 | 15% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Bachelor | 8 | 9% |
| Lecturer | 6 | 7% |
| Other | 17 | 20% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 18% |
| Medicine and Dentistry | 12 | 14% |
| Chemistry | 8 | 9% |
| Nursing and Health Professions | 7 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 14 | 16% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2023.
All research outputs
#1,125,217
of 25,880,422 outputs
Outputs from Cell Biology and Toxicology
#4
of 533 outputs
Outputs of similar age
#8,083
of 210,703 outputs
Outputs of similar age from Cell Biology and Toxicology
#1
of 2 outputs
Altmetric has tracked 25,880,422 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 533 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them