| Title |
Wnt signaling and cellular metabolism in osteoblasts
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2016
|
| DOI | 10.1007/s00018-016-2425-5 |
| Pubmed ID | |
| Authors |
Courtney M. Karner, Fanxin Long |
| Abstract |
The adult human skeleton is a multifunctional organ undergoing continuous remodeling. Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone resorption by osteoclasts and bone formation by osteoblasts; disturbance of such balance is the root cause for various bone disorders including osteoporosis. To develop effective and safe therapeutics to modulate bone formation, it is essential to elucidate the molecular mechanisms governing osteoblast differentiation and activity. Due to their specialized function in collagen synthesis and secretion, osteoblasts are expected to consume large amounts of nutrients. However, studies of bioenergetics and building blocks in osteoblasts have been lagging behind those of growth factors and transcription factors. Genetic studies in both humans and mice over the past 15 years have established Wnt signaling as a critical mechanism for stimulating osteoblast differentiation and activity. Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. Such findings therefore reveal an important regulatory axis between bone anabolic signals and cellular bioenergetics. A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 182 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 19% |
| Student > Bachelor | 22 | 12% |
| Student > Master | 18 | 10% |
| Student > Doctoral Student | 16 | 9% |
| Researcher | 12 | 7% |
| Other | 19 | 10% |
| Unknown | 61 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 19% |
| Medicine and Dentistry | 33 | 18% |
| Agricultural and Biological Sciences | 18 | 10% |
| Engineering | 10 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 14 | 8% |
| Unknown | 67 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2017.
All research outputs
#14,873,797
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,871
of 4,151 outputs
Outputs of similar age
#230,141
of 420,715 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#25
of 37 outputs
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