| Title |
Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2008
|
| DOI | 10.1007/s00018-008-8103-5 |
| Pubmed ID | |
| Authors |
A. Salminen, M. Lehtonen, T. Suuronen, K. Kaarniranta, J. Huuskonen |
| Abstract |
Traditional medicine has been a fertile source for revealing novel lead molecules for modern drug discovery. In plants, terpenoids represent a chemical defense against environmental stress and provide a repair mechanism for wounds and injuries. Interestingly, effective ingredients in several plant-derived medicinal extracts are also terpenoid compounds of monoterpenoid, sesquiterpenoid, diterpenoid, triterpenoid and carotenoid groups. Inflammatory diseases and cancer are typical therapeutic indications of traditional medicines. Thus folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-kappaB (NF-kappaB) signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.We review the extensive literature on the different types of terpenoid molecules, totalling 43, which have been verified both inhibiting the NF-kappaB signaling and suppressing the process of inflammation and cancer. It seems that during evolution, plants have established a terpene-based host defense which also represents a cornucopia of effective therapeutic compounds for common human diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Turkey | 1 | <1% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 314 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 19% |
| Student > Master | 41 | 13% |
| Researcher | 38 | 12% |
| Student > Bachelor | 31 | 10% |
| Student > Postgraduate | 17 | 5% |
| Other | 60 | 19% |
| Unknown | 72 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 21% |
| Biochemistry, Genetics and Molecular Biology | 44 | 14% |
| Chemistry | 41 | 13% |
| Medicine and Dentistry | 26 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 8% |
| Other | 30 | 9% |
| Unknown | 86 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#3,416,356
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#533
of 4,151 outputs
Outputs of similar age
#10,121
of 83,879 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 35 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,879 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.