| Title |
Aberrant Cerebellar Neurotrophin-3 Expression Induced by Lipopolysaccharide Exposure During Brain Development
|
|---|---|
| Published in |
The Cerebellum, January 2013
|
| DOI | 10.1007/s12311-012-0446-7 |
| Pubmed ID | |
| Authors |
Ming Xu, Elizabeth M. Sajdel-Sulkowska, Toshiharu Iwasaki, Noriyuki Koibuchi |
| Abstract |
Autism is a developmental disorder affecting communication, social interaction, motor skills, and cerebellar structure and functions. Recent studies have indicated that maternal infection during brain development may be one of the risk factors for autism. We have previously demonstrated the abnormal overexpression of neurotrophin-3 (NT-3) in autistic cerebellum. To examine further the potential link between autism and maternal infection, and specifically NT-3 expression in the cerebellum, we used maternal lipopolysaccharide (LPS)-exposed rat model of infection. In group 1, pregnant female rats were exposed to 200 μg/kg body weight LPS delivered subcutaneously from gestational days (G) 10 to G15, and pups were exposed to LPS from postnatal days (P) 5 to P10, whereas in group 2, pups were exposed to the same dose of LPS from P5 to P10. There was no change in body mass of pups and mothers following LPS treatment. Cerebellar NT-3 levels were examined by enzyme-linked immunosorbent assay on P6, P12, and P21. We report here that cerebellar NT-3 levels were elevated in pups of both LPS groups as compared to the controls on P21. Our results suggest that altered neurotrophin levels may affect normal brain development and contribute to autistic pathology. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 28% |
| Student > Bachelor | 6 | 10% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Postgraduate | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 10 | 17% |
| Unknown | 11 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 24% |
| Psychology | 11 | 19% |
| Agricultural and Biological Sciences | 6 | 10% |
| Medicine and Dentistry | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2013.
All research outputs
#5,985,942
of 23,975,976 outputs
Outputs from The Cerebellum
#130
of 957 outputs
Outputs of similar age
#67,040
of 313,747 outputs
Outputs of similar age from The Cerebellum
#2
of 15 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 957 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,747 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.