| Title |
Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats
|
|---|---|
| Published in |
Cancer Chemotherapy and Pharmacology, January 2010
|
| DOI | 10.1007/s00280-010-1253-9 |
| Pubmed ID | |
| Authors |
Kazuma Hamada, Yoshihisa Shitara, Shuichi Sekine, Toshiharu Horie |
| Abstract |
The molecular mechanisms that underlie the methotrexate (MTX)-mediated disruption of intestinal barrier function have not been fully characterized. Epithelial barrier function is determined in large part by a multiprotein complex located at the most apical part of the lateral membrane, which is referred to as a tight junction (TJ). In the present study, we examined the alteration of zonula occludens-1 (ZO-1), which is a scaffolding protein that plays a pivotal role in the formation of TJs, to identify an additional molecular mechanism for epithelial barrier dysfunction. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 18% |
| Researcher | 6 | 16% |
| Student > Master | 6 | 16% |
| Student > Bachelor | 5 | 13% |
| Student > Postgraduate | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 21% |
| Agricultural and Biological Sciences | 7 | 18% |
| Medicine and Dentistry | 7 | 18% |
| Immunology and Microbiology | 3 | 8% |
| Chemistry | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 9 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2012.
All research outputs
#5,894,850
of 23,815,455 outputs
Outputs from Cancer Chemotherapy and Pharmacology
#545
of 2,501 outputs
Outputs of similar age
#37,825
of 169,173 outputs
Outputs of similar age from Cancer Chemotherapy and Pharmacology
#8
of 22 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,501 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,173 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.