| Title |
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2011
|
| DOI | 10.1007/s00018-011-0844-x |
| Pubmed ID | |
| Authors |
H. A. Tejeda, T. S. Shippenberg, R. Henriksson |
| Abstract |
The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function. We overview the pharmacology, signaling, post-translational, post-transcriptional, transcriptional, epigenetic and cis regulation of the dynorphin/κ-opioid receptor system, and critically review functional neuroanatomical, neurochemical, and pharmacological evidence, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia. We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development. |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Spain | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 125 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 18% |
| Researcher | 18 | 14% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 10 | 8% |
| Other | 8 | 6% |
| Other | 26 | 20% |
| Unknown | 30 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 17% |
| Agricultural and Biological Sciences | 20 | 16% |
| Medicine and Dentistry | 17 | 13% |
| Psychology | 16 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 15 | 12% |
| Unknown | 32 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2019.
All research outputs
#2,748,530
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#409
of 4,151 outputs
Outputs of similar age
#14,495
of 139,056 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 37 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,056 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.