| Title |
Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, February 2009
|
| DOI | 10.1007/s10803-009-0707-6 |
| Pubmed ID | |
| Authors |
Natalia M. Kleinhans, Todd Richards, Kurt E. Weaver, Olivia Liang, Geraldine Dawson, Elizabeth Aylward |
| Abstract |
Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD. |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 2 | 2% |
| Germany | 1 | <1% |
| Costa Rica | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 98 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 18% |
| Researcher | 15 | 14% |
| Student > Master | 14 | 13% |
| Professor > Associate Professor | 9 | 8% |
| Student > Bachelor | 8 | 8% |
| Other | 25 | 24% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 26 | 25% |
| Medicine and Dentistry | 22 | 21% |
| Neuroscience | 11 | 10% |
| Agricultural and Biological Sciences | 5 | 5% |
| Social Sciences | 4 | 4% |
| Other | 19 | 18% |
| Unknown | 19 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2009.
All research outputs
#6,239,764
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#2,292
of 5,240 outputs
Outputs of similar age
#28,694
of 96,888 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#11
of 31 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,240 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,888 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.