| Title |
Expression of GABAB Receptors Is Altered in Brains of Subjects with Autism
|
|---|---|
| Published in |
The Cerebellum, November 2008
|
| DOI | 10.1007/s12311-008-0075-3 |
| Pubmed ID | |
| Authors |
S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, Paul D. Thuras |
| Abstract |
Autism is a neurodevelopmental disorder that is often comorbid with seizures. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain. GABA(B) receptors play an important role in maintaining excitatory-inhibitory balance in brain and alterations may lead to seizures. We compared levels of GABA(B) receptor subunits GABA(B) receptor 1 (GABBR1) and GABA(B) receptor 2 (GABBR2) in cerebellum, Brodmann's area 9 (BA9), and BA40 of subjects with autism and matched controls. Levels of GABBR1 were significantly decreased in BA9, BA40, and cerebellum, while GABBR2 was significantly reduced in the cerebellum. The presence of seizure disorder did not have a significant impact on the observed reductions in GABA(B) receptor subunit expression. Decreases in GABA(B) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Ethiopia | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 170 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 25% |
| Researcher | 24 | 13% |
| Student > Bachelor | 19 | 11% |
| Student > Master | 18 | 10% |
| Student > Doctoral Student | 16 | 9% |
| Other | 33 | 18% |
| Unknown | 25 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 23% |
| Neuroscience | 34 | 19% |
| Medicine and Dentistry | 25 | 14% |
| Psychology | 22 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 6% |
| Other | 14 | 8% |
| Unknown | 31 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2022.
All research outputs
#2,935,050
of 24,677,985 outputs
Outputs from The Cerebellum
#45
of 973 outputs
Outputs of similar age
#8,987
of 94,173 outputs
Outputs of similar age from The Cerebellum
#1
of 9 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 973 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,173 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them