| Title |
Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study
|
|---|---|
| Published in |
European Child & Adolescent Psychiatry, December 2016
|
| DOI | 10.1007/s00787-016-0933-3 |
| Pubmed ID | |
| Authors |
Lorraine C. Als, Maria D. Picouto, Kieran J. O’Donnell, Simon Nadel, Mehrengise Cooper, Christine M. Pierce, Tami Kramer, Vivette A. S. Glover, M. Elena Garralda |
| Abstract |
In this exploratory case-control study, we investigated basal cortisol regulation in 5-16-year-old children, 3-6 months following PICU (paediatric intensive care) admission. This was nested within a study of child psychological and cognitive function; 47 children were assessed alongside 56 healthy controls. Saliva samples were collected three times per day (immediately after waking, waking +30 min, and waking +12 h) over two consecutive weekdays. In addition, data on posttraumatic stress symptoms were ascertained from 33 PICU admitted children using the Impact of Events Scale-8 (IES-8). Primary analysis revealed no significant differences in basal cortisol concentrations between PICU discharged children and healthy controls (p > 0.05). Secondary analysis in the PICU group identified a significant positive association between posttraumatic stress symptoms and evening (waking +12 h) cortisol concentrations (p = 0.004). However, when subject to multivariate analysis, evening cortisol was a modest independent predictor of IES-8 scores, relative to the presence of septic illness and poor pre-morbid health. We conclude that paediatric critical illness does not appear to result in marked perturbations to basal cortisol at 3-6 month following discharge. There was evidence of a link between evening cortisol and symptoms of PTSD, but this was not a robust effect and requires further elucidation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 1% |
| Unknown | 91 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 22% |
| Student > Bachelor | 11 | 12% |
| Student > Ph. D. Student | 10 | 11% |
| Student > Doctoral Student | 7 | 8% |
| Researcher | 6 | 7% |
| Other | 14 | 15% |
| Unknown | 24 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 26% |
| Psychology | 16 | 17% |
| Nursing and Health Professions | 6 | 7% |
| Agricultural and Biological Sciences | 3 | 3% |
| Social Sciences | 3 | 3% |
| Other | 13 | 14% |
| Unknown | 27 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2017.
All research outputs
#17,837,681
of 22,914,829 outputs
Outputs from European Child & Adolescent Psychiatry
#1,353
of 1,647 outputs
Outputs of similar age
#293,063
of 420,355 outputs
Outputs of similar age from European Child & Adolescent Psychiatry
#19
of 25 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,647 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,355 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.