| Title |
Perspectives of biotechnological production of l-tyrosine and its applications
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, October 2007
|
| DOI | 10.1007/s00253-007-1243-y |
| Pubmed ID | |
| Authors |
Tina Lütke-Eversloh, Christine Nicole S. Santos, Gregory Stephanopoulos |
| Abstract |
The aromatic amino acid L-tyrosine is used as a dietary supplement and has promise as a valuable precursor compound for various industrial and pharmaceutical applications. In contrast to chemical production, biotechnological methods can produce L-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing L-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more recent advances. Whereas early attempts to engineer L-tyrosine-excreting microbes were based on auxotrophic and antimetabolite-resistant mutants, recombinant deoxyribonucleic acid technology and a vastly increasing knowledge of bacterial physiology allowed recently for more targeted genetic manipulations and strain improvements. As an alternative route, L-tyrosine can also be obtained from the conversion of phenol, pyruvate, and ammonia or phenol and serine in reactions catalyzed by the enzyme tyrosine phenol lyase. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Mexico | 1 | <1% |
| China | 1 | <1% |
| Unknown | 152 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 23% |
| Researcher | 28 | 18% |
| Student > Master | 21 | 13% |
| Student > Bachelor | 14 | 9% |
| Professor | 9 | 6% |
| Other | 16 | 10% |
| Unknown | 35 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 26% |
| Biochemistry, Genetics and Molecular Biology | 33 | 21% |
| Chemistry | 15 | 9% |
| Engineering | 10 | 6% |
| Chemical Engineering | 5 | 3% |
| Other | 13 | 8% |
| Unknown | 42 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#2,476,826
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#223
of 8,034 outputs
Outputs of similar age
#5,799
of 78,829 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#4
of 34 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,034 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.