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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Archaic Adaptive Introgression in TBX15/WARS2
|
|---|---|
| Published in |
Molecular Biology and Evolution, December 2016
|
| DOI | 10.1093/molbev/msw283 |
| Pubmed ID | |
| Authors |
Fernando Racimo, David Gokhman, Matteo Fumagalli, Amy Ko, Torben Hansen, Ida Moltke, Anders Albrechtsen, Liran Carmel, Emilia Huerta-Sánchez, Rasmus Nielsen |
| Abstract |
A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using SNP chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome, and was likely introgressed from an archaic population. The region contains two genes, WARS2 and TBX15, and has previously been associated with adipose tissue differentiation and body-fat distribution in humans. We show that the adaptively introgressed allele has been under selection in a much larger geographic region than just Greenland. Furthermore, it is associated with changes in expression of WARS2 and TBX15 in multiple tissues including the adrenal gland and subcutaneous adipose tissue, and with regional DNA methylation changes in TBX15. |
X Demographics
The data shown below were collected from the profiles of 48 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 23% |
| United Kingdom | 4 | 8% |
| Spain | 3 | 6% |
| France | 2 | 4% |
| Hong Kong | 1 | 2% |
| Comoros | 1 | 2% |
| Germany | 1 | 2% |
| Bosnia and Herzegovina | 1 | 2% |
| Japan | 1 | 2% |
| Other | 8 | 17% |
| Unknown | 15 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 23 | 48% |
| Members of the public | 23 | 48% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Portugal | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 193 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 25% |
| Student > Master | 28 | 14% |
| Researcher | 27 | 14% |
| Student > Bachelor | 21 | 11% |
| Other | 10 | 5% |
| Other | 29 | 14% |
| Unknown | 36 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 28% |
| Biochemistry, Genetics and Molecular Biology | 52 | 26% |
| Social Sciences | 11 | 6% |
| Environmental Science | 8 | 4% |
| Medicine and Dentistry | 5 | 3% |
| Other | 29 | 14% |
| Unknown | 39 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 343. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2023.
All research outputs
#92,567
of 24,917,903 outputs
Outputs from Molecular Biology and Evolution
#26
of 5,192 outputs
Outputs of similar age
#2,192
of 432,186 outputs
Outputs of similar age from Molecular Biology and Evolution
#1
of 73 outputs
Altmetric has tracked 24,917,903 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,192 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 432,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.