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Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)

Overview of attention for article published in Pharmacology, Biochemistry & Behavior, July 2002
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
2 news outlets
blogs
2 blogs
twitter
2 X users
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5 patents
facebook
1 Facebook page
reddit
1 Redditor
video
5 YouTube creators

Citations

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199 Dimensions

Readers on

mendeley
234 Mendeley
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2 CiteULike
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Title
Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm)
Published in
Pharmacology, Biochemistry & Behavior, July 2002
DOI 10.1016/s0091-3057(02)00777-3
Pubmed ID
Authors

D.O Kennedy, Andrew B Scholey, N.T.J Tildesley, E.K Perry, K.A Wesnes

Abstract

Melissa officinalis (lemon balm) is a traditional herbal medicine, which enjoys contemporary usage as a mild sedative, spasmolytic and antibacterial agent. It has been suggested, in light of in vitro cholinergic binding properties, that Melissa extracts may effectively ameliorate the cognitive deficits associated with Alzheimer's disease. To date, no study has investigated the effects on cognition and mood of administration of Melissa to healthy humans. The present randomised, placebo-controlled, double-blind, balanced-crossover study investigated the acute effects on cognition and mood of a standardised extract of M. officinalis. Twenty healthy, young participants received single doses of 300, 600 and 900 mg of M. officinalis (Pharmaton) or a matching placebo at 7-day intervals. Cognitive performance was assessed using the Cognitive Drug Research (CDR) computerised test battery and two serial subtraction tasks immediately prior to dosing and at 1, 2.5, 4 and 6 h thereafter. In vitro IC(50) concentrations for the displacement of [3H]-(N)-nicotine and [3H]-(N)-scopolamine from nicotinic and muscarinic receptors in human occipital cortex tissue were also calculated. Results, utilising the cognitive factors previously derived from the CDR battery, included a sustained improvement in Accuracy of Attention following 600 mg of Melissa and time- and dose-specific reductions in both Secondary Memory and Working Memory factors. Self-rated "calmness," as assessed by Bond-Lader mood scales, was elevated at the earliest time points by the lowest dose, whilst "alertness" was significantly reduced at all time points following the highest dose. Both nicotinic and muscarinic binding were found to be low in comparison to the levels found in previous studies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Australia 1 <1%
Austria 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Unknown 227 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 38 16%
Researcher 35 15%
Student > Master 35 15%
Other 21 9%
Student > Ph. D. Student 16 7%
Other 32 14%
Unknown 57 24%
Readers by discipline Count As %
Medicine and Dentistry 46 20%
Agricultural and Biological Sciences 36 15%
Biochemistry, Genetics and Molecular Biology 16 7%
Pharmacology, Toxicology and Pharmaceutical Science 16 7%
Psychology 14 6%
Other 38 16%
Unknown 68 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2023.
All research outputs
#1,235,565
of 25,394,764 outputs
Outputs from Pharmacology, Biochemistry & Behavior
#79
of 3,160 outputs
Outputs of similar age
#1,007
of 47,920 outputs
Outputs of similar age from Pharmacology, Biochemistry & Behavior
#2
of 17 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,160 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 47,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.