| Title |
Aripiprazole in the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorder in Japan: A Randomized, Double-blind, Placebo-controlled Study
|
|---|---|
| Published in |
Child Psychiatry & Human Development, December 2016
|
| DOI | 10.1007/s10578-016-0704-x |
| Pubmed ID | |
| Authors |
Hironobu Ichikawa, Katsunaka Mikami, Takashi Okada, Yushiro Yamashita, Yuko Ishizaki, Akemi Tomoda, Hiroaki Ono, Chiharu Usuki, Yoshihiro Tadori |
| Abstract |
We evaluated the efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents (6-17 years) with autism spectrum disorder (ASD) in a randomized, double-blind, placebo-controlled 8-week study in Japan. Patients received flexibly dosed aripiprazole (1-15 mg/day) or placebo. Ninety-two patients were randomized to placebo (n = 45) or aripiprazole (n = 47). Aripiprazole produced a significant improvement in the mean parent/caregiver-rated Aberrant Behavior Checklist Japanese Version irritability subscale score relative to placebo from week 3 through week 8. Administration of aripiprazole provided significantly greater improvement in the mean clinician-rated Clinical Global Impression-Improvement scores than placebo from week 2 through week 8. All patients randomized to aripiprazole completed the study, and no serious adverse events were reported. Three patients in placebo group discontinued. Aripiprazole was effective and generally safe and well-tolerated in the treatment of irritability associated with ASD in Japanese children and adolescents. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 6 | 38% |
| United States | 1 | 6% |
| China | 1 | 6% |
| Unknown | 8 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 88% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 14% |
| Student > Bachelor | 18 | 11% |
| Researcher | 17 | 11% |
| Other | 12 | 8% |
| Student > Ph. D. Student | 12 | 8% |
| Other | 31 | 20% |
| Unknown | 46 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 26% |
| Psychology | 25 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Nursing and Health Professions | 9 | 6% |
| Neuroscience | 9 | 6% |
| Other | 14 | 9% |
| Unknown | 51 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2023.
All research outputs
#1,895,403
of 25,321,938 outputs
Outputs from Child Psychiatry & Human Development
#60
of 1,010 outputs
Outputs of similar age
#37,744
of 433,943 outputs
Outputs of similar age from Child Psychiatry & Human Development
#2
of 8 outputs
Altmetric has tracked 25,321,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,010 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.