| Title |
Association between IL8 haplotypes and pathogen levels in chronic periodontitis
|
|---|---|
| Published in |
European Journal of Clinical Microbiology & Infectious Diseases, May 2013
|
| DOI | 10.1007/s10096-013-1884-y |
| Pubmed ID | |
| Authors |
L. S. Finoti, S. C. T. Corbi, G. Anovazzi, S. R. L. Teixeira, J. P. Steffens, R. Secolin, Y. J. Kim, S. R. P. Orrico, J. A. Cirelli, M. P. A. Mayer, R. M. Scarel-Caminaga |
| Abstract |
Chronic periodontitis (CP) is considered to be a multifactorial disease influenced by microbial and genetic factors. The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/TTC haplotype is associated with subgingival levels of periodontopathogens. Sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the IL8 haplotype, were evaluated. After clinical periodontal evaluation, each group was subdivided according to the presence (CP) or absence (H) of periodontitis. Four subgingival samples were obtained from CP and two samples per subject from H patients. The levels and proportions of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were analyzed using quantitative real-time polymerase chain reaction (q-PCR). No differences were found in the proportion of periodontopathogenic bacteria between groups with the presence or absence of the IL8 haplotype. However, in the CP groups, the levels of periodontopathogens were significantly higher in the individuals without the IL8 haplotype than in the individuals with the IL8 haplotype. These results suggest that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/TTC haplotype than in patients without this haplotype. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 5 | 31% |
| Student > Bachelor | 3 | 19% |
| Student > Master | 2 | 13% |
| Researcher | 2 | 13% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 69% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Neuroscience | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2013.
All research outputs
#15,272,611
of 22,711,242 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#1,863
of 2,768 outputs
Outputs of similar age
#119,685
of 193,513 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#17
of 22 outputs
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