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Premature Cell Senescence and T Cell Receptor–Independent Activation of CD8+ T Cells in Juvenile Idiopathic Arthritis

Overview of attention for article published in Arthritis & Rheumatism, July 2013
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Title
Premature Cell Senescence and T Cell Receptor–Independent Activation of CD8+ T Cells in Juvenile Idiopathic Arthritis
Published in
Arthritis & Rheumatism, July 2013
DOI 10.1002/art.38015
Pubmed ID
Authors

Jeffrey A. Dvergsten, Robert G. Mueller, Patricia Griffin, Sameem Abedin, Allyson Pishko, Joshua J. Michel, Margalit E. Rosenkranz, Ann M. Reed, Daniel A. Kietz, Abbe N. Vallejo

Abstract

CD8+ T cells lacking CD28 were originally reported to be a characteristic feature of juvenile idiopathic arthritis (JIA), but the relevance of these unusual cells to this disease remains to be elucidated. Because of recent evidence that loss of CD28 cells is typical of terminally differentiated lymphocytes, the aim of this study was to examine functional subsets of CD8+ T cells in patients with JIA.

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Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Singapore 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 21%
Researcher 7 16%
Student > Ph. D. Student 6 14%
Student > Bachelor 4 9%
Professor > Associate Professor 2 5%
Other 5 12%
Unknown 10 23%
Readers by discipline Count As %
Medicine and Dentistry 15 35%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 5 12%
Immunology and Microbiology 4 9%
Arts and Humanities 1 2%
Other 3 7%
Unknown 9 21%