| Title |
The role of gut microbiota in the gut-brain axis: current challenges and perspectives
|
|---|---|
| Published in |
Protein & Cell, May 2013
|
| DOI | 10.1007/s13238-013-3017-x |
| Pubmed ID | |
| Authors |
Xiao Chen, Roshan D’Souza, Seong-Tshool Hong |
| Abstract |
Brain and the gastrointestinal (GI) tract are intimately connected to form a bidirectional neurohumoral communication system. The communication between gut and brain, knows as the gut-brain axis, is so well established that the functional status of gut is always related to the condition of brain. The researches on the gut-brain axis were traditionally focused on the psychological status affecting the function of the GI tract. However, recent evidences showed that gut microbiota communicates with the brain via the gut-brain axis to modulate brain development and behavioral phenotypes. These recent findings on the new role of gut microbiota in the gut-brain axis implicate that gut microbiota could associate with brain functions as well as neurological diseases via the gut-brain axis. To elucidate the role of gut microbiota in the gut-brain axis, precise identification of the composition of microbes constituting gut microbiota is an essential step. However, identification of microbes constituting gut microbiota has been the main technological challenge currently due to massive amount of intestinal microbes and the difficulties in culture of gut microbes. Current methods for identification of microbes constituting gut microbiota are dependent on omics analysis methods by using advanced high tech equipment. Here, we review the association of gut microbiota with the gut-brain axis, including the pros and cons of the current high throughput methods for identification of microbes constituting gut microbiota to elucidate the role of gut microbiota in the gut-brain axis. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Practitioners (doctors, other healthcare professionals) | 3 | 43% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Hungary | 1 | <1% |
| Australia | 1 | <1% |
| India | 1 | <1% |
| South Africa | 1 | <1% |
| Denmark | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 295 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 66 | 22% |
| Student > Master | 50 | 16% |
| Student > Ph. D. Student | 42 | 14% |
| Researcher | 32 | 10% |
| Student > Postgraduate | 14 | 5% |
| Other | 48 | 16% |
| Unknown | 53 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 27% |
| Medicine and Dentistry | 44 | 14% |
| Biochemistry, Genetics and Molecular Biology | 32 | 10% |
| Psychology | 19 | 6% |
| Immunology and Microbiology | 15 | 5% |
| Other | 55 | 18% |
| Unknown | 58 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2021.
All research outputs
#1,301,702
of 25,654,806 outputs
Outputs from Protein & Cell
#45
of 821 outputs
Outputs of similar age
#10,311
of 209,629 outputs
Outputs of similar age from Protein & Cell
#1
of 15 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 821 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.