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Mendeley readers
Attention Score in Context
| Title |
STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
|
|---|---|
| Published in |
Cancer Research, February 2013
|
| DOI | 10.1158/0008-5472.can-12-1875 |
| Pubmed ID | |
| Authors |
Cristina Peña, María Virtudes Céspedes, Maja Bradic Lindh, Sara Kiflemariam, Artur Mezheyeuski, Per-Henrik Edqvist, Christina Hägglöf, Helgi Birgisson, Linda Bojmar, Karin Jirström, Per Sandström, Eleonor Olsson, Srinivas Veerla, Alberto Gallardo, Tobias Sjöblom, Andy C.-M. Chang, Roger R. Reddel, Ramón Mangues, Martin Augsten, Arne Östman |
| Abstract |
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Netherlands | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| India | 1 | <1% |
| Unknown | 144 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 28% |
| Researcher | 29 | 19% |
| Student > Master | 20 | 13% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 27% |
| Biochemistry, Genetics and Molecular Biology | 33 | 22% |
| Medicine and Dentistry | 33 | 22% |
| Chemistry | 3 | 2% |
| Immunology and Microbiology | 3 | 2% |
| Other | 10 | 7% |
| Unknown | 28 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2013.
All research outputs
#20,194,150
of 22,711,242 outputs
Outputs from Cancer Research
#16,790
of 17,845 outputs
Outputs of similar age
#253,567
of 287,612 outputs
Outputs of similar age from Cancer Research
#153
of 164 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 17,845 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,612 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 164 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.