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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways
|
|---|---|
| Published in |
Nature Immunology, May 2013
|
| DOI | 10.1038/ni.2607 |
| Pubmed ID | |
| Authors |
Jiyeon S Kim, Tammarah Sklarz, Lauren B Banks, Mercy Gohil, Adam T Waickman, Nicolas Skuli, Bryan L Krock, Chong T Luo, Weihong Hu, Kristin N Pollizzi, Ming O Li, Jeffrey C Rathmell, Morris J Birnbaum, Jonathan D Powell, Martha S Jordan, Gary A Koretzky |
| Abstract |
Natural T helper 17 (nTH17) cells are a population of interleukin 17 (IL-17)-producing cells that acquire effector function in the thymus during development. Here we demonstrate that the serine/threonine kinase Akt has a critical role in regulating nTH17 cell development. Although Akt and the downstream mTORC1-ARNT-HIFα axis were required for generation of inducible TH17 (iTH17) cells, nTH17 cells developed independently of mTORC1. In contrast, mTORC2 and inhibition of Foxo proteins were critical for development of nTH17 cells. Moreover, distinct isoforms of Akt controlled the generation of TH17 cell subsets, as deletion of Akt2, but not of Akt1, led to defective generation of iTH17 cells. These findings define mechanisms regulating nTH17 cell development and reveal previously unknown roles of Akt and mTOR in shaping subsets of T cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Ireland | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 152 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 27% |
| Student > Ph. D. Student | 34 | 21% |
| Professor | 19 | 12% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 10 | 6% |
| Other | 27 | 17% |
| Unknown | 13 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 43% |
| Immunology and Microbiology | 26 | 16% |
| Medicine and Dentistry | 24 | 15% |
| Biochemistry, Genetics and Molecular Biology | 15 | 9% |
| Chemistry | 2 | 1% |
| Other | 5 | 3% |
| Unknown | 19 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#1,266,028
of 25,784,004 outputs
Outputs from Nature Immunology
#820
of 4,236 outputs
Outputs of similar age
#9,675
of 205,595 outputs
Outputs of similar age from Nature Immunology
#7
of 42 outputs
Altmetric has tracked 25,784,004 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,236 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.