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Chaperone-independent mitochondrial translocation and protection by αB-crystallin in RPE cells

Overview of attention for article published in Experimental Eye Research, March 2013
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Title
Chaperone-independent mitochondrial translocation and protection by αB-crystallin in RPE cells
Published in
Experimental Eye Research, March 2013
DOI 10.1016/j.exer.2013.02.016
Pubmed ID
Authors

Rebecca S. McGreal, Lisa A. Brennan, Wanda Lee Kantorow, Jeffrey D. Wilcox, Jianning Wei, Daniel Chauss, Marc Kantorow

Abstract

αB-crystallin is a small heat shock protein that exhibits chaperone activity and can protect multiple cell types against oxidative stress damage. Altered levels and specific mutations of αB-crystallin are associated with multiple degenerative diseases. We previously found that αB-crystallin translocates to lens and retinal cell mitochondria upon oxidative stress exposure where it provides protection against oxidative stress damage. To date, the role of the chaperone function of αB-crystallin in mitochondrial translocation and protection has not been established. Here, we sought to determine the relationship between the chaperone activity of αB-crystallin and its ability to translocate to and protect retinal cell mitochondria against oxidative stress damage. Our data provide evidence that three forms of αB-crystallin exhibiting different chaperone activity levels including wild-type, R120G (decreased chaperone activity) and M68A (increased chaperone activity) provide comparable levels of mitochondrial translocation and protection to retinal cells exposed to oxidative stress. The results provide evidence that mitochondrial translocation and protection by αB-crystallin is independent of its chaperone activity and that other functions of αB-crystallin may also be independent of its chaperone activity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Researcher 3 19%
Other 2 13%
Professor > Associate Professor 2 13%
Student > Master 2 13%
Other 1 6%
Unknown 2 13%
Readers by discipline Count As %
Medicine and Dentistry 4 25%
Biochemistry, Genetics and Molecular Biology 2 13%
Chemistry 2 13%
Neuroscience 2 13%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2013.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Experimental Eye Research
#2,292
of 2,935 outputs
Outputs of similar age
#160,225
of 207,607 outputs
Outputs of similar age from Experimental Eye Research
#14
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,935 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.