Title |
Mitochondrial and skeletal muscle health with advancing age
|
---|---|
Published in |
Molecular & Cellular Endocrinology, May 2013
|
DOI | 10.1016/j.mce.2013.05.008 |
Pubmed ID | |
Authors |
Adam R. Konopka, K. Sreekumaran Nair |
Abstract |
With increasing age there is a temporal relationship between the decline of mitochondrial and skeletal muscle volume, quality and function (i.e., health). Reduced mitochondrial mRNA expression, protein abundance, and protein synthesis rates appear to promote the decline of mitochondrial protein quality and function. Decreased mitochondrial function is suspected to impede energy demanding processes such as skeletal muscle protein turnover, which is critical for maintaining protein quality and thus skeletal muscle health with advancing age. The focus of this review was to discuss promising human physiological systems underpinning the decline of mitochondrial and skeletal muscle health with advancing age while highlighting therapeutic strategies such as aerobic exercise and caloric restriction for combating age-related functional impairments. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 13% |
United Kingdom | 2 | 13% |
Canada | 1 | 6% |
Guatemala | 1 | 6% |
Germany | 1 | 6% |
Australia | 1 | 6% |
Ireland | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 56% |
Scientists | 5 | 31% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 111 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 17% |
Student > Master | 19 | 17% |
Student > Bachelor | 16 | 14% |
Researcher | 16 | 14% |
Student > Postgraduate | 7 | 6% |
Other | 22 | 19% |
Unknown | 15 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 25% |
Agricultural and Biological Sciences | 25 | 22% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Sports and Recreations | 9 | 8% |
Nursing and Health Professions | 6 | 5% |
Other | 11 | 10% |
Unknown | 22 | 19% |