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A family affair: brain abnormalities in siblings of patients with schizophrenia

Overview of attention for article published in Brain, May 2013
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Title
A family affair: brain abnormalities in siblings of patients with schizophrenia
Published in
Brain, May 2013
DOI 10.1093/brain/awt116
Pubmed ID
Authors

Marcel E. Moran, Hilleke Hulshoff Pol, Nitin Gogtay

Abstract

Schizophrenia is a severe mental disorder that has a strong genetic basis. Converging evidence suggests that schizophrenia is a progressive neurodevelopmental disorder, with earlier onset cases resulting in more profound brain abnormalities. Siblings of patients with schizophrenia provide an invaluable resource for differentiating between trait and state markers, thus highlighting possible endophenotypes for ongoing research. However, findings from sibling studies have not been systematically put together in a coherent story across the broader age span. We review here the cortical grey matter abnormalities in siblings of patients with schizophrenia from childhood to adulthood, by reviewing sibling studies from both childhood-onset schizophrenia, and the more common adult-onset schizophrenia. When reviewed together, studies suggest that siblings of patients with schizophrenia display significant brain abnormalities that highlight both similarities and differences between the adult and childhood populations, with shared developmental risk patterns, and segregating trajectories. Based on current research it appears that the cortical grey matter abnormalities in siblings are likely to be an age-dependent endophenotype, which normalize by the typical age of onset of schizophrenia unless there has been more genetic or symptom burdening. With increased genetic burdening (e.g. discordant twins of patients) the grey matter abnormalities in (twin) siblings are progressive in adulthood. This synthesis of the literature clarifies the importance of brain plasticity in the pathophysiology of the illness, indicating that probands may lack protective factors critical for healthy development.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Netherlands 1 1%
Italy 1 1%
Unknown 86 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Researcher 13 15%
Student > Master 13 15%
Student > Bachelor 9 10%
Professor 6 7%
Other 18 20%
Unknown 12 13%
Readers by discipline Count As %
Neuroscience 19 21%
Psychology 17 19%
Medicine and Dentistry 15 17%
Agricultural and Biological Sciences 11 12%
Social Sciences 3 3%
Other 4 4%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2013.
All research outputs
#14,617,807
of 25,402,889 outputs
Outputs from Brain
#6,127
of 7,604 outputs
Outputs of similar age
#109,312
of 208,216 outputs
Outputs of similar age from Brain
#54
of 87 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,604 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,216 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.