| Title |
Adherence and Acceptability in MTN 001: A Randomized Cross-Over Trial of Daily Oral and Topical Tenofovir for HIV Prevention in Women
|
|---|---|
| Published in |
AIDS and Behavior, October 2012
|
| DOI | 10.1007/s10461-012-0333-8 |
| Pubmed ID | |
| Authors |
Alexandra M. Minnis, Sharavi Gandham, Barbra A. Richardson, Vijayanand Guddera, Beatrice A. Chen, Robert Salata, Clemensia Nakabiito, Craig Hoesley, Jessica Justman, Lydia Soto-Torres, Karen Patterson, Kailazarid Gomez, Craig W. Hendrix |
| Abstract |
We compared adherence to and acceptability of daily topical and oral formulations of tenofovir (TFV) used as pre-exposure prophylaxis (PrEP) for HIV prevention among women in South Africa, Uganda and the United States. 144 sexually active, HIV-uninfected women participated in a cross-over study of three regimens: oral tablet, vaginal gel, or both. We tested for differences in adherence and evaluated product acceptability. Self-reported adherence for all regimens was high (94 %), but serum TFV concentrations indicated only 64 % of participants used tablets consistently. Most women in the U.S. (72 %) favored tablets over gel; while preferences varied at the African sites (42 % preferred gel and 40 % tablets). Findings indicate a role for oral and vaginal PrEP formulations and highlight the importance of integrating pharmacokinetics-based adherence assessment in future trials. Biomedical HIV prevention interventions should consider geographic and cultural experience with product formulations, partner involvement, and sexual health benefits that ultimately influence use. |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Malaysia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 170 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 16% |
| Student > Ph. D. Student | 25 | 14% |
| Student > Master | 20 | 11% |
| Other | 11 | 6% |
| Student > Bachelor | 11 | 6% |
| Other | 42 | 24% |
| Unknown | 40 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 25% |
| Nursing and Health Professions | 21 | 12% |
| Social Sciences | 21 | 12% |
| Psychology | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 26 | 15% |
| Unknown | 48 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2015.
All research outputs
#3,393,167
of 25,331,507 outputs
Outputs from AIDS and Behavior
#486
of 3,681 outputs
Outputs of similar age
#22,941
of 182,420 outputs
Outputs of similar age from AIDS and Behavior
#8
of 76 outputs
Altmetric has tracked 25,331,507 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,681 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,420 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.