| Title |
The Activity of Adiponectin in Bone
|
|---|---|
| Published in |
Calcified Tissue International, December 2016
|
| DOI | 10.1007/s00223-016-0216-5 |
| Pubmed ID | |
| Authors |
Dorit Naot, David S. Musson, Jillian Cornish |
| Abstract |
The adipokine adiponectin affects multiple target tissues and plays important roles in glucose metabolism and whole-body energy homeostasis. Circulating adiponectin levels in obese people are lower than in non-obese, and increased serum adiponectin is associated with weight loss. Numerous clinical studies have established that fat mass is positively related to bone mass, a relationship that is maintained by communication between the two tissues through hormones and cytokines. Since adiponectin levels inversely correspond to fat mass, its bone effects and its potential contribution to the relationship between fat and bone have been investigated. In clinical observational studies, adiponectin was found to be negatively associated with bone mineral density, suggesting it might be a negative regulator of bone metabolism. In order to identify the mechanisms that underlie the activity of adiponectin in bone, a large number of laboratory studies in vitro and in animal models of mice over-expressing or deficient of adiponectin have been carried out. Results of these studies are not entirely congruent, partly due to variation among experimental systems and partly due to the complex nature of adiponectin signaling, which involves a combination of multiple direct and indirect mechanisms. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 16% |
| Student > Bachelor | 8 | 13% |
| Student > Postgraduate | 6 | 10% |
| Student > Doctoral Student | 6 | 10% |
| Student > Master | 5 | 8% |
| Other | 10 | 16% |
| Unknown | 18 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 24% |
| Biochemistry, Genetics and Molecular Biology | 9 | 14% |
| Agricultural and Biological Sciences | 6 | 10% |
| Unspecified | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 23 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2016.
All research outputs
#20,376,559
of 22,925,760 outputs
Outputs from Calcified Tissue International
#1,569
of 1,761 outputs
Outputs of similar age
#353,802
of 419,772 outputs
Outputs of similar age from Calcified Tissue International
#15
of 19 outputs
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