| Title |
A New Perspective for Parkinson’s Disease: Circadian Rhythm
|
|---|---|
| Published in |
Neuroscience Bulletin, December 2016
|
| DOI | 10.1007/s12264-016-0089-7 |
| Pubmed ID | |
| Authors |
Siyue Li, Yali Wang, Fen Wang, Li-Fang Hu, Chun-Feng Liu |
| Abstract |
Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Brazil | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 167 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 14% |
| Student > Bachelor | 22 | 13% |
| Student > Master | 20 | 12% |
| Researcher | 17 | 10% |
| Student > Doctoral Student | 13 | 8% |
| Other | 18 | 11% |
| Unknown | 54 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 32 | 19% |
| Medicine and Dentistry | 23 | 14% |
| Agricultural and Biological Sciences | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 15 | 9% |
| Psychology | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 62 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2022.
All research outputs
#1,445,623
of 23,322,966 outputs
Outputs from Neuroscience Bulletin
#18
of 797 outputs
Outputs of similar age
#31,670
of 422,791 outputs
Outputs of similar age from Neuroscience Bulletin
#2
of 9 outputs
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So far Altmetric has tracked 797 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 97% of its peers.
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