| Title |
Defining the Role of Cerebellar Purkinje Cells in Autism Spectrum Disorders
|
|---|---|
| Published in |
The Cerebellum, May 2013
|
| DOI | 10.1007/s12311-013-0490-y |
| Pubmed ID | |
| Authors |
Anamaria Sudarov |
| Abstract |
Understanding the contribution of cerebellar dysfunction to complex neurological diseases such as autism spectrum disorders (ASD) is an ongoing topic of investigation. In a recent paper, Tsai et al. (Nature 488:647-651, 2012) used a powerful combination of conditional mouse genetics, electrophysiology, behavioral tests, and pharmacological manipulations to address the role of Tuberous sclerosis complex 1 (Tsc1) in Purkinje cells and cerebellar function. The authors make the staggering discovery that morphological and electrophysiological defects in Purkinje cells are linked to system-wide ASD-like behavioral deficits. In this journal club, I discuss the major findings of this paper and critically assess the implications of this seminal work. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| India | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 83 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Researcher | 15 | 17% |
| Student > Bachelor | 14 | 16% |
| Student > Master | 13 | 15% |
| Student > Postgraduate | 6 | 7% |
| Other | 14 | 16% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 21% |
| Agricultural and Biological Sciences | 16 | 19% |
| Psychology | 14 | 16% |
| Medicine and Dentistry | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Other | 6 | 7% |
| Unknown | 16 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2020.
All research outputs
#15,095,138
of 25,654,806 outputs
Outputs from The Cerebellum
#349
of 998 outputs
Outputs of similar age
#112,021
of 208,330 outputs
Outputs of similar age from The Cerebellum
#4
of 21 outputs
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So far Altmetric has tracked 998 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.