| Title |
Antifungal Activity of Nanocapsule Suspensions Containing Tea Tree Oil on the Growth of Trichophyton rubrum
|
|---|---|
| Published in |
Mycopathologia, February 2013
|
| DOI | 10.1007/s11046-013-9622-7 |
| Pubmed ID | |
| Authors |
F. C. Flores, J. A. de Lima, R. F. Ribeiro, S. H. Alves, C. M. B. Rolim, R. C. R. Beck, Cristiane Bona da Silva |
| Abstract |
The aim of this study was to evaluate, for the first time, the antifungal efficacy of nanocapsules and nanoemulsions containing Melaleuca alternifolia essential oil (tea tree oil) in an onychomycosis model. The antifungal activity of nanostructured formulations was evaluated against Trichophyton rubrum in two different in vitro models of dermatophyte nail infection. First, nail powder was infected with T. rubrum in a 96-well plate and then treated with the formulations. After 7 and 14 days, cell viability was verified. The plate counts for the samples were 2.37, 1.45 and 1.0 log CFU mL(-1) (emulsion, nanoemulsion containing tea tree oil and nanocapsules containing tea tree oil, respectively). A second model employed nails fragments which were infected with the microorganism and treated with the formulations. The diameter of fungal colony was measured. The areas obtained were 2.88 ± 2.08 mm(2), 14.59 ± 2.01 mm(2), 40.98 ± 2.76 mm(2) and 38.72 ± 1.22 mm(2) for the nanocapsules containing tea tree oil, nanoemulsion containing tea tree oil, emulsion and untreated nail, respectively. Nail infection models demonstrated the ability of the formulations to reduce T. rubrum growth, with the inclusion of oil in nanocapsules being most efficient. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 123 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 17 | 14% |
| Student > Bachelor | 16 | 13% |
| Student > Ph. D. Student | 15 | 12% |
| Student > Master | 12 | 10% |
| Professor > Associate Professor | 6 | 5% |
| Other | 19 | 15% |
| Unknown | 40 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 18% |
| Agricultural and Biological Sciences | 14 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Medicine and Dentistry | 8 | 6% |
| Chemistry | 7 | 6% |
| Other | 19 | 15% |
| Unknown | 46 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#581,330
of 24,274,366 outputs
Outputs from Mycopathologia
#6
of 1,132 outputs
Outputs of similar age
#4,675
of 292,273 outputs
Outputs of similar age from Mycopathologia
#1
of 4 outputs
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So far Altmetric has tracked 1,132 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 99% of its peers.
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