Title |
Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progeny
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Published in |
Bulletin of Environmental Contamination and Toxicology, December 2016
|
DOI | 10.1007/s00128-016-2006-1 |
Pubmed ID | |
Authors |
J. Lemos, T. Neuparth, M. Trigo, P. Costa, D. Vieira, L. Cunha, F. Ponte, P. S. Costa, L. F. Metello, A. P. Carvalho |
Abstract |
This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 3% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 32% |
Researcher | 6 | 19% |
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Lecturer | 2 | 6% |
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Medicine and Dentistry | 1 | 3% |
Other | 1 | 3% |
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