| Title |
Etiology of Type II Diabetes Mellitus: Role of the Foregut
|
|---|---|
| Published in |
World Journal of Surgery, April 2014
|
| DOI | 10.1007/s002680020348 |
| Pubmed ID | |
| Authors |
Walter J. Pories, Robert J. Albrecht |
| Abstract |
The Greenville version of the gastric bypass induced long-term remission of type II diabetes mellitus in 121 of 146 (82.9%) morbidly obese patients. Similarly, the operation returned 150 of 152 (98.7%) morbidly obese patients with impaired glucose tolerance to euglycemia. These outcomes were not merely changes in glucose levels; the operation also reduced the mortality and morbidity of the disease. Diabetic patients submitted to surgery had a 1.0% chance of dying during a 10-year period of follow-up compared to a mortality rate of 4.5% in a matched group (p = 0.0003). These results, the best therapeutic outcomes for type II diabetes ever reported, suggest that the disease is not an untreatable, hopeless illness but one that can be treated successfully with better understanding of the pathophysiology of these surgical remissions. The mechanism of the improvement is not yet clear. The rapidity of the correction to euglycemia, usually a matter of days, suggests that the reason is not the loss of weight (i.e., reduction in fat mass) but, rather, the result of the exclusion of food and a secondary alteration in incretin signals from the antrum, duodenum, and proximal jejunum to the islets. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 74 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 16% |
| Student > Bachelor | 12 | 16% |
| Student > Master | 9 | 12% |
| Student > Ph. D. Student | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Other | 14 | 18% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 38% |
| Agricultural and Biological Sciences | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Nursing and Health Professions | 3 | 4% |
| Unspecified | 2 | 3% |
| Other | 8 | 11% |
| Unknown | 23 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#2,627,200
of 23,342,092 outputs
Outputs from World Journal of Surgery
#364
of 4,297 outputs
Outputs of similar age
#27,050
of 227,947 outputs
Outputs of similar age from World Journal of Surgery
#5
of 94 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,297 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,947 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.