Title |
Adult monozygotic twins discordant for intra-uterine growth have indistinguishable genome-wide DNA methylation profiles
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Published in |
Genome Biology, May 2013
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DOI | 10.1186/gb-2013-14-5-r44 |
Pubmed ID | |
Authors |
Nicole YP Souren, Pavlo Lutsik, Gilles Gasparoni, Sascha Tierling, Jasmin Gries, Matthias Riemenschneider, Jean-Pierre Fryns, Catherine Derom, Maurice P Zeegers, Jörn Walter |
Abstract |
Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intra-uterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of metabolic genes. To address this, we acquire genome-wide DNA methylation profiles from saliva DNA in a unique cohort of 17 monozygotic monochorionic female twins very discordant for birth weight. We examine if adverse prenatal growth conditions experienced by the smaller co-twins lead to long-lasting DNA methylation changes. |
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Geographical breakdown
Country | Count | As % |
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United States | 4 | 40% |
United Kingdom | 1 | 10% |
Australia | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 70% |
Scientists | 2 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 2% |
Italy | 1 | 1% |
Germany | 1 | 1% |
United Kingdom | 1 | 1% |
Luxembourg | 1 | 1% |
Unknown | 80 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 22% |
Student > Ph. D. Student | 17 | 20% |
Student > Master | 7 | 8% |
Student > Bachelor | 6 | 7% |
Professor > Associate Professor | 6 | 7% |
Other | 17 | 20% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 29 | 34% |
Medicine and Dentistry | 16 | 19% |
Biochemistry, Genetics and Molecular Biology | 11 | 13% |
Nursing and Health Professions | 4 | 5% |
Chemistry | 3 | 3% |
Other | 8 | 9% |
Unknown | 15 | 17% |