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Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines

Overview of attention for article published in Genes, Chromosomes, and Cancer, November 2005
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

blogs
1 blog

Citations

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35 Dimensions

Readers on

mendeley
25 Mendeley
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Title
Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines
Published in
Genes, Chromosomes, and Cancer, November 2005
DOI 10.1002/gcc.20290
Pubmed ID
Authors

Juliet D. French, Jasmyn Dunn, Chanel E. Smart, Nathan Manning, Melissa A. Brown

Abstract

BRCA1 is a tumor suppressor that functions in controlling cell growth and maintaining genomic stability. BRCA1 has also been implicated in telomere maintenance through its ability to regulate the transcription of hTERT, the catalytic subunit of telomerase, resulting in telomere shortening, and to colocalize with the telomere-binding protein TRF1. The high incidence of nonreciprocal translocations in tumors arising from BRCA1 mutation carriers and Brca1-null mice also raises the possibility that BRCA1 plays a role in telomere protection. To date, however, the consequences for telomere status of disrupting BRCA1 have not been reported. To examine the role of BRCA1 in telomere regulation, we have expressed a dominant-negative mutant of BRCA1 (trBRCA1), known to disrupt multiple functions of BRCA1, in telomerase-positive mammary epithelial cells (SVCT) and telomerase-negative ALT cells (GM847). In SVCT cells, expression of trBRCA1 resulted in an increased incidence of anaphase bridges and in an increase in telomere length, but no change in telomerase activity. In GM847 cells, trBRCA1 also increased anaphase bridge formation but did not induce any change in telomere length. BRCA1 colocalized with TRF2 in telomerase-positive cells and with a small subset of ALT-associated PML bodies (APBs) in ALT cells. Together, these results raise the possibility that BRCA1 could play a role in telomere protection and suggest a potential mechanism for one of the phenotypes of BRCA1-deficient cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Ph. D. Student 4 16%
Student > Bachelor 3 12%
Student > Master 2 8%
Student > Doctoral Student 1 4%
Other 2 8%
Unknown 8 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 28%
Agricultural and Biological Sciences 7 28%
Medicine and Dentistry 2 8%
Physics and Astronomy 1 4%
Unknown 8 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2013.
All research outputs
#3,798,611
of 25,373,627 outputs
Outputs from Genes, Chromosomes, and Cancer
#100
of 1,541 outputs
Outputs of similar age
#8,092
of 76,666 outputs
Outputs of similar age from Genes, Chromosomes, and Cancer
#1
of 4 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,541 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,666 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them