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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure
|
|---|---|
| Published in |
JACC: Basic to Translational Science, December 2016
|
| DOI | 10.1016/j.jacbts.2016.09.005 |
| Pubmed ID | |
| Authors |
Daniel J. Lenihan, Sarah A. Anderson, Carrie Geisberg Lenneman, Evan Brittain, James A.S. Muldowney, Lisa Mendes, Ping Z. Zhao, Jennifer Iaci, Stephen Frohwein, Ronald Zolty, Andrew Eisen, Douglas B. Sawyer, Anthony O. Caggiano |
| Abstract |
A first-in-human, phase 1, double blind, placebo-controlled, single ascending dose study examined the safety, tolerability, and exploratory efficacy of intravenous infusion of a recombinant growth factor, cimaglermin alfa, in patients with heart failure and left ventricular systolic dysfunction (LVSD). In these patients on optimal guideline-directed medical therapy, cimaglermin treatment was generally tolerated except for transient nausea and headache and a dose-limiting toxicity was noted at the highest planned dose. There was a dose-dependent improvement in left ventricular ejection fraction lasting 90 days following infusion. Thus, cimaglermin is a potential therapy to enhance cardiac function in LVSD and warrants further investigation. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 14% |
| United States | 5 | 14% |
| Netherlands | 2 | 6% |
| United Kingdom | 2 | 6% |
| Pakistan | 1 | 3% |
| Mexico | 1 | 3% |
| Uruguay | 1 | 3% |
| Georgia | 1 | 3% |
| Germany | 1 | 3% |
| Other | 6 | 17% |
| Unknown | 11 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 81% |
| Practitioners (doctors, other healthcare professionals) | 3 | 8% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 21% |
| Researcher | 7 | 16% |
| Other | 5 | 12% |
| Student > Master | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Medicine and Dentistry | 9 | 21% |
| Agricultural and Biological Sciences | 4 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 5 | 12% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 224. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#173,030
of 25,608,265 outputs
Outputs from JACC: Basic to Translational Science
#11
of 815 outputs
Outputs of similar age
#3,691
of 423,373 outputs
Outputs of similar age from JACC: Basic to Translational Science
#2
of 21 outputs
Altmetric has tracked 25,608,265 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 815 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,373 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.