| Title |
Genetics of obesity: can an old dog teach us new tricks?
|
|---|---|
| Published in |
Diabetologia, December 2016
|
| DOI | 10.1007/s00125-016-4187-x |
| Pubmed ID | |
| Authors |
Giles S. H. Yeo |
| Abstract |
At one level, obesity is clearly a problem of simple physics, a result of eating too much and not expending enough energy. The more complex question, however, is why do some people eat more than others? Studies of human and mouse genetics over the past two decades have uncovered a number of pathways within the brain that play a key role in the control of food intake. A prime example is the leptin-melanocortin pathway, which we now know greatly contributes to mammalian appetitive behaviour. However, genetic disruption of this pathway remains rare and does not represent the major burden of the disease that is carried by those of us with 'common obesity'. In recent years, genome-wide association studies have revealed more than 100 different candidate genes linked to BMI, with most (including many components of the melanocortin pathway) acting in the central nervous system and influencing food intake. So while severe disruption of the melanocortin pathway results in severe obesity, subtle variations in these genes influence where you might sit in the normal distribution of BMI. As we now enter this 'post-genomics' world, can this new information influence our treatment and management of obese patients? |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 15 | 23% |
| United States | 9 | 14% |
| Canada | 4 | 6% |
| Netherlands | 4 | 6% |
| Finland | 2 | 3% |
| Italy | 1 | 2% |
| Chile | 1 | 2% |
| Spain | 1 | 2% |
| India | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 26 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 52% |
| Scientists | 18 | 28% |
| Practitioners (doctors, other healthcare professionals) | 9 | 14% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Unknown | 138 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 30 | 22% |
| Student > Ph. D. Student | 22 | 16% |
| Student > Master | 22 | 16% |
| Researcher | 15 | 11% |
| Student > Doctoral Student | 6 | 4% |
| Other | 18 | 13% |
| Unknown | 26 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 25% |
| Medicine and Dentistry | 23 | 17% |
| Agricultural and Biological Sciences | 23 | 17% |
| Veterinary Science and Veterinary Medicine | 9 | 6% |
| Psychology | 4 | 3% |
| Other | 13 | 9% |
| Unknown | 32 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2021.
All research outputs
#1,092,148
of 25,547,904 outputs
Outputs from Diabetologia
#568
of 5,361 outputs
Outputs of similar age
#22,261
of 423,203 outputs
Outputs of similar age from Diabetologia
#15
of 65 outputs
Altmetric has tracked 25,547,904 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,361 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.