| Title |
Calcium signaling triggered by ouabain protects the embryonic kidney from adverse developmental programming
|
|---|---|
| Published in |
Pediatric Nephrology, March 2011
|
| DOI | 10.1007/s00467-011-1816-y |
| Pubmed ID | |
| Authors |
Georgiy R. Khodus, Markus Kruusmägi, Juan Li, Xiao-Li Liu, Anita Aperia |
| Abstract |
The kidney is extraordinarily sensitive to adverse fetal programming. Malnutrition, the most common form of developmental challenge, retards formation of the kidney's functional units, the nephrons. The resulting low nephron endowment increases susceptibility to renal injury and disease. Using explanted rat embryonic kidneys, we found that the sodium-potassium-adenosine triphosphatase (Na, K-ATPase) ligand ouabain triggers, via the Na, K-ATPase/ inositol 1,4,5-trisphosphate receptor signalosome, a calcium-nuclear factor-kappa B (NF-κB) signal that protects kidney development from adverse effects of malnutrition. Serum deprivation resulted in severe retardation of nephron formation and robust increase in apoptotic rate, but in ouabain-exposed kidneys, no adverse effects of serum deprivation were observed. Depletion of intracellular calcium stores and inhibition of NF-κB activity abolished the rescuing effect of ouabain. Proof of principle that ouabain rescues development of embryonic kidneys exposed to malnutrition was obtained from studies on pregnant rats given low-protein diets and treated with ouabain or vehicle throughout pregnancy. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 6% |
| United States | 1 | 6% |
| Unknown | 14 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Lecturer | 4 | 25% |
| Researcher | 3 | 19% |
| Other | 2 | 13% |
| Student > Ph. D. Student | 2 | 13% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Other | 4 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 25% |
| Agricultural and Biological Sciences | 3 | 19% |
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Nursing and Health Professions | 1 | 6% |
| Business, Management and Accounting | 1 | 6% |
| Other | 4 | 25% |
| Unknown | 1 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2012.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from Pediatric Nephrology
#3,820
of 4,063 outputs
Outputs of similar age
#112,368
of 119,414 outputs
Outputs of similar age from Pediatric Nephrology
#12
of 13 outputs
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So far Altmetric has tracked 4,063 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.