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Mitochondrial injury and cognitive function in HIV infection and methamphetamine use

Overview of attention for article published in AIDS, March 2016
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Title
Mitochondrial injury and cognitive function in HIV infection and methamphetamine use
Published in
AIDS, March 2016
DOI 10.1097/qad.0000000000001027
Pubmed ID
Authors

Susanna R. Var, Tyler R.C. Day, Andrej Vitomirov, Davey M. Smith, Virawudh Soontornniyomkij, David J. Moore, Cristian L. Achim, Sanjay R. Mehta, Josué Pérez-Santiago

Abstract

In this work we evaluated the association of human immunodeficiency virus (HIV) infection and methamphetamine (METH) use with mitochondrial injury in the brain and its implication on neurocognitive impairment. Mitochondria carry their genome (mtDNA) and play a critical role in cellular processes in the central nervous system. METH is commonly used in HIV-infected populations. HIV infection and METH use can cause damage to mtDNA and lead to neurocognitive morbidity. We evaluated HIV infection and METH use with mitochondrial injury in the brain. We obtained white and gray matter from Brodmann's areas (BA) BA7, BA8, BA9, and BA46 of a) HIV-infected individuals with history of past METH use (HIV+METH+, n = 16), b) HIV-infected individuals with no history of past METH use (HIV+METH-, n = 11), and c) HIV-negative controls (HIV-METH-, n = 30). We used the "common deletion," a 4,977 bp mutation, as a measurement of mitochondrial injury, and quantified levels of mtDNA and "common deletion" by droplet digital PCR, and evaluated in relation to neurocognitive functioning (Global Deficit Score [GDS]). Levels of mtDNA and mitochondrial injury were highest in white matter of BA46. A higher relative proportion of mtDNA carrying the "common deletion" was associated with lower GDS (p < 0.01) in HIV+METH+ but higher GDS (p < 0.01) in HIV+METH-. Increased mitochondrial injury was associated with worse neurocognitive function in HIV+METH- individuals. Among HIV+METH+ individuals, an opposite effect was seen.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 18%
Researcher 8 14%
Student > Master 7 12%
Student > Bachelor 4 7%
Other 4 7%
Other 8 14%
Unknown 16 28%
Readers by discipline Count As %
Medicine and Dentistry 9 16%
Agricultural and Biological Sciences 4 7%
Nursing and Health Professions 4 7%
Psychology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 13 23%
Unknown 20 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2016.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from AIDS
#5,167
of 6,479 outputs
Outputs of similar age
#193,315
of 315,570 outputs
Outputs of similar age from AIDS
#37
of 69 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,479 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,570 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.