| Title |
Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, January 2002
|
| DOI | 10.1385/jmn:18:3:265 |
| Pubmed ID | |
| Authors |
Smita Kittur, Skuntala Wilasrusmee, Ward A. Pedersen, Mark. P. Mattson, Karen Straube-West, Chumpon Wilasrusmee, Burk Jubelt, Dilip S. Kittur |
| Abstract |
Herbal products are being increasingly used as dietary supplements and therapeutic agents. However, much more research must be performed in order to determine the biological basis for their putative clinical effects. We tested the effects of milk thistle (Silybum marianum) extract on the differentiation and survival of cultured neural cells. Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death. Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival, suggesting potential benefits of chemicals in this plant on the nervous system. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 35% |
| Student > Bachelor | 6 | 19% |
| Other | 2 | 6% |
| Professor | 2 | 6% |
| Student > Doctoral Student | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 19% |
| Agricultural and Biological Sciences | 6 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
| Physics and Astronomy | 2 | 6% |
| Business, Management and Accounting | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 8 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2023.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Journal of Molecular Neuroscience
#1,156
of 1,643 outputs
Outputs of similar age
#126,179
of 130,776 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#17
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,776 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.