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Combinatorial Gene Regulation through Kinetic Control of the Transcription Cycle

Overview of attention for article published in Cell Systems, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
39 X users

Citations

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68 Dimensions

Readers on

mendeley
188 Mendeley
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1 CiteULike
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Title
Combinatorial Gene Regulation through Kinetic Control of the Transcription Cycle
Published in
Cell Systems, December 2016
DOI 10.1016/j.cels.2016.11.012
Pubmed ID
Authors

Clarissa Scholes, Angela H. DePace, Álvaro Sánchez

Abstract

Cells decide when, where, and to what level to express their genes by "computing" information from transcription factors (TFs) binding to regulatory DNA. How is the information contained in multiple TF-binding sites integrated to dictate the rate of transcription? The dominant conceptual and quantitative model is that TFs combinatorially recruit one another and RNA polymerase to the promoter by direct physical interactions. Here, we develop a quantitative framework to explore kinetic control, an alternative model in which combinatorial gene regulation can result from TFs working on different kinetic steps of the transcription cycle. Kinetic control can generate a wide range of analog and Boolean computations without requiring the input TFs to be simultaneously bound to regulatory DNA. We propose experiments that will illuminate the role of kinetic control in transcription and discuss implications for deciphering the cis-regulatory "code."

X Demographics

X Demographics

The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Portugal 1 <1%
Czechia 1 <1%
Germany 1 <1%
Taiwan 1 <1%
United States 1 <1%
Unknown 181 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 60 32%
Researcher 52 28%
Student > Bachelor 22 12%
Student > Master 12 6%
Student > Doctoral Student 9 5%
Other 21 11%
Unknown 12 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 70 37%
Agricultural and Biological Sciences 57 30%
Engineering 10 5%
Physics and Astronomy 9 5%
Medicine and Dentistry 7 4%
Other 17 9%
Unknown 18 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2020.
All research outputs
#1,797,605
of 25,371,288 outputs
Outputs from Cell Systems
#416
of 981 outputs
Outputs of similar age
#35,976
of 422,386 outputs
Outputs of similar age from Cell Systems
#10
of 33 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 981 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.