Title |
Dyslipidemia in patients with chronic kidney disease
|
---|---|
Published in |
Reviews in Endocrine and Metabolic Disorders, December 2016
|
DOI | 10.1007/s11154-016-9402-z |
Pubmed ID | |
Authors |
Matthew R. Hager, Archana D. Narla, Lisa R. Tannock |
Abstract |
Chronic kidney disease (CKD) is associated with high risk for cardiovascular disease (CVD). This association is multifactorial, but CKD is often associated with dyslipidemia, which likely contributes. Patients with CKD have dyslipidemia even at early stages of renal dysfunction and dyslipidemia tends to progress with deterioration of kidney function. The dyslipidemia in CKD is largely due to increased triglyceride levels, decreased HDL-C and varying levels of LDL-C. Current management of CKD may also affect lipid levels. Robust clinical trials demonstrate that statins are safe and efficacious in both lipid lowering and prevention of CVD events in pre-end stage CKD and post-transplant. However, there is no evidence of improved CVD outcomes with statin use in dialysis patients. This review will focus on mechanisms underlying dyslipidemia in CKD and clinical trial evidence for lipid lowering therapy in patients with CKD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | <1% |
Unknown | 119 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 13 | 11% |
Student > Master | 13 | 11% |
Student > Bachelor | 13 | 11% |
Student > Ph. D. Student | 9 | 8% |
Student > Doctoral Student | 8 | 7% |
Other | 25 | 21% |
Unknown | 39 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 37% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Nursing and Health Professions | 6 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 12 | 10% |
Unknown | 44 | 37% |