| Title |
Venous thromboembolic events in critically ill traumatic brain injury patients
|
|---|---|
| Published in |
Intensive Care Medicine, December 2016
|
| DOI | 10.1007/s00134-016-4655-2 |
| Pubmed ID | |
| Authors |
Markus B. Skrifvars, Michael Bailey, Jeffrey Presneill, Craig French, Alistair Nichol, Lorraine Little, Jacques Duranteau, Olivier Huet, Samir Haddad, Yaseen Arabi, Colin McArthur, D. James Cooper, Rinaldo Bellomo, For the EPO-TBI investigators and the ANZICS Clinical Trials Group |
| Abstract |
To estimate the prevalence, risk factors, prophylactic treatment and impact on mortality for venous thromboembolism (VTE) in patients with moderate to severe traumatic brain injury (TBI) treated in the intensive care unit. A post hoc analysis of the erythropoietin in traumatic brain injury (EPO-TBI) trial that included twice-weekly lower limb ultrasound screening. Venous thrombotic events were defined as ultrasound-proven proximal deep venous thrombosis (DVT) or clinically detected pulmonary embolism (PE). Results are reported as events, percentages or medians and interquartile range (IQR). Cox regression analysis was used to calculate adjusted hazard ratios (HR) with 95% confidence intervals (CI) for time to VTE and death. Of 603 patients, 119 (19.7%) developed VTE, mostly comprising DVT (102 patients, 16.9%) with a smaller number of PE events (24 patients, 4.0%). Median time to DVT diagnosis was 6 days (IQR 2-11) and to PE diagnosis 6.5 days (IQR 2-16.5). Mechanical prophylaxis (MP) was used in 91% of patients on day 1, 97% of patients on day 3 and 98% of patients on day 7. Pharmacological prophylaxis was given in 5% of patients on day 1, 30% of patients on day 3 and 57% of patients on day 7. Factors associated with time to VTE were age (HR per year 1.02, 95% CI 1.01-1.03), patient weight (HR per kg 1.01, 95% CI 1-1.02) and TBI severity according to the International Mission for Prognosis and Analysis of Clinical Trials risk of poor outcome (HR per 10% increase 1.12, 95% CI 1.01-1.25). The development of VTE was not associated with mortality (HR 0.92, 95% CI 0.51-1.65). Despite mechanical and pharmacological prophylaxis, VTE occurs in one out of every five patients with TBI treated in the ICU. Higher age, greater weight and greater severity of TBI increase the risk. The development of VTE was not associated with excess mortality. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 13% |
| United Kingdom | 2 | 7% |
| Spain | 2 | 7% |
| Argentina | 1 | 3% |
| Denmark | 1 | 3% |
| Ecuador | 1 | 3% |
| Russia | 1 | 3% |
| Malaysia | 1 | 3% |
| Mexico | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 12 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 53% |
| Practitioners (doctors, other healthcare professionals) | 8 | 27% |
| Science communicators (journalists, bloggers, editors) | 3 | 10% |
| Scientists | 3 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 16% |
| Other | 21 | 14% |
| Student > Bachelor | 15 | 10% |
| Student > Master | 14 | 10% |
| Student > Ph. D. Student | 11 | 8% |
| Other | 28 | 19% |
| Unknown | 34 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 71 | 49% |
| Biochemistry, Genetics and Molecular Biology | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Neuroscience | 4 | 3% |
| Computer Science | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 50 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2020.
All research outputs
#1,474,252
of 25,773,273 outputs
Outputs from Intensive Care Medicine
#1,303
of 5,492 outputs
Outputs of similar age
#29,548
of 424,849 outputs
Outputs of similar age from Intensive Care Medicine
#12
of 75 outputs
Altmetric has tracked 25,773,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,492 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one has done well, scoring higher than 76% of its peers.
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We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.