↓ Skip to main content

Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia

Overview of attention for article published in Journal of Psychiatric Research, January 2017
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
73 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia
Published in
Journal of Psychiatric Research, January 2017
DOI 10.1016/j.jpsychires.2016.12.020
Pubmed ID
Authors

Rahim Mohd Nabil Fikri, A. Talib Norlelawati, Abdul Rahim Nour El-Huda, Mohd Noor Hanisah, Abdullah Kartini, Kuzaifah Norsidah, Abdullah Nor Zamzila

Abstract

The epigenetic changes of RELN that are involved in the development of dopaminergic neurons may fit the developmental theory of schizophrenia. However, evidence regarding the association of RELN DNA methylation with schizophrenia is far from sufficient, as studies have only been conducted on a few limited brain samples. As DNA methylation in the peripheral blood may mirror the changes taking place in the brain, the use of peripheral blood for a DNA methylation study in schizophrenia is feasible due to the scarcity of brain samples. Therefore, the aim of our study was to examine the relationship of DNA methylation levels of RELN promoters with schizophrenia using genomic DNA derived from the peripheral blood of patients with the disorder. The case control studies consisted of 110 schizophrenia participants and 122 healthy controls who had been recruited from the same district. After bisufhite conversion, the methylation levels of the DNA samples were calculated based on their differences of the Cq values assayed using the highly sensitive real-time MethyLight TaqMan(®) procedure. A significantly higher level of methylation of the RELN promoter was found in patients with schizophrenia compared to controls (p = 0.005) and also in males compared with females (p = 0.004). Subsequently, the RELN expression of the methylated group was 25 fold less than that of the non-methylated group. Based upon the assumption of parallel methylation changes in the brain and peripheral blood, we concluded that RELN DNA methylation might contribute to the pathogenesis of schizophrenia. However, the definite effects of methylation on RELN function during development and also in adult life still require further elaboration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 22 30%
Student > Master 11 15%
Student > Ph. D. Student 8 11%
Researcher 6 8%
Lecturer 2 3%
Other 6 8%
Unknown 18 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 21%
Medicine and Dentistry 12 16%
Neuroscience 11 15%
Agricultural and Biological Sciences 5 7%
Nursing and Health Professions 3 4%
Other 8 11%
Unknown 19 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2022.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Journal of Psychiatric Research
#2,722
of 3,857 outputs
Outputs of similar age
#267,838
of 421,653 outputs
Outputs of similar age from Journal of Psychiatric Research
#44
of 54 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,857 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,653 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.