| Title |
Deubiquitylating Enzymes and DNA Damage Response Pathways
|
|---|---|
| Published in |
Cell Biochemistry and Biophysics, May 2013
|
| DOI | 10.1007/s12013-013-9635-3 |
| Pubmed ID | |
| Authors |
Xavier Jacq, Mark Kemp, Niall M. B. Martin, Stephen P. Jackson |
| Abstract |
Covalent post-translational modification of proteins by ubiquitin and ubiquitin-like factors has emerged as a general mechanism to regulate myriad intra-cellular processes. The addition and removal of ubiquitin or ubiquitin-like proteins from factors has recently been demonstrated as a key mechanism to modulate DNA damage response (DDR) pathways. It is thus, timely to evaluate the potential for ubiquitin pathway enzymes as DDR drug targets for therapeutic intervention. The synthetic lethal approach provides exciting opportunities for the development of targeted therapies to treat cancer: most tumours have lost critical DDR pathways, and thus rely more heavily on the remaining pathways, while normal tissues are still equipped with all DDR pathways. Here, we review key deubiquitylating enzymes (DUBs) involved in DDR pathways, and describe how targeting DUBs may lead to selective therapies to treat cancer patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 163 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 24% |
| Researcher | 38 | 23% |
| Student > Master | 27 | 16% |
| Student > Bachelor | 11 | 7% |
| Professor > Associate Professor | 9 | 5% |
| Other | 28 | 17% |
| Unknown | 13 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 34% |
| Agricultural and Biological Sciences | 54 | 33% |
| Medicine and Dentistry | 19 | 11% |
| Chemistry | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 10 | 6% |
| Unknown | 16 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2020.
All research outputs
#6,926,349
of 22,711,242 outputs
Outputs from Cell Biochemistry and Biophysics
#110
of 910 outputs
Outputs of similar age
#59,276
of 195,012 outputs
Outputs of similar age from Cell Biochemistry and Biophysics
#6
of 30 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 910 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.