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Breast Cancer Metastatic Progression Requires mRNA Posttranscriptional Suppression.

Overview of attention for article published in Cancer Research, July 2023
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Article details
Title
Breast Cancer Metastatic Progression Requires mRNA Posttranscriptional Suppression.
Published in
Cancer Research, July 2023
DOI 10.1158/0008-5472.can-23-1729
Pubmed ID
Authors
Abstract

Cancer cell survival is highly dependent on its metabolic reprogramming, which supports not only cell growth but also confers to the tumor cells characteristics to initiate migration and colonization. Among the different mechanisms that are involved, translational control plays a significant role in oncogenesis; however, its impact on cancer progression still remains poorly understood. A study by Navickas and colleagues revealed that the RNA-binding protein heterogeneous nuclear ribonucleoprotein C (HNRNPC) functions as a translational regulator, and its downregulation in highly metastatic cells leads to the lengthening of 3' untranslated regions in HNRNPC-bound mRNAs, resulting in translational repression mediated by the AGO-miRNA RNA-induced silencing complex.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2023.
All research outputs
#27,749,292
of 34,387,656 outputs
Outputs from Cancer Research
#33,002
of 35,515 outputs
Outputs of similar age
#284,759
of 394,980 outputs
Outputs of similar age from Cancer Research
#78
of 89 outputs
Altmetric has tracked 34,387,656 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 35,515 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.