| Title |
The zebrafish as a model for studying neuroblastoma
|
|---|---|
| Published in |
Cancer Cell International, November 2016
|
| DOI | 10.1186/s12935-016-0360-z |
| Pubmed ID | |
| Authors |
Diana Corallo, Simona Candiani, Michela Ori, Sanja Aveic, Gian Paolo Tonini |
| Abstract |
Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and progression remain unknown, the generation of new in vivo models might be appropriate to better dissect the peripheral sympathetic nervous system development in both physiological and disease states. This review is focused on the use of zebrafish as a suitable and innovative model to study neuroblastoma development. Here, we briefly summarize the current knowledge about zebrafish peripheral sympathetic nervous system formation, focusing on key genes and cellular pathways that play a crucial role in the differentiation of sympathetic neurons during embryonic development. In addition, we include examples of how genetic changes known to be associated with aggressive neuroblastoma can mimic this malignancy in zebrafish. Thus, we note the value of the zebrafish model in the field of neuroblastoma research, showing how it can improve our current knowledge about genes and biological pathways that contribute to malignant transformation and progression during embryonic life. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 21% |
| Researcher | 8 | 15% |
| Student > Master | 8 | 15% |
| Student > Bachelor | 6 | 11% |
| Professor | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 15 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 26% |
| Biochemistry, Genetics and Molecular Biology | 12 | 23% |
| Medicine and Dentistry | 6 | 11% |
| Environmental Science | 1 | 2% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 17 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2016.
All research outputs
#20,376,559
of 22,925,760 outputs
Outputs from Cancer Cell International
#1,361
of 1,807 outputs
Outputs of similar age
#269,255
of 311,716 outputs
Outputs of similar age from Cancer Cell International
#5
of 5 outputs
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