| Title |
Glia: silent partners in energy homeostasis and obesity pathogenesis
|
|---|---|
| Published in |
Diabetologia, December 2016
|
| DOI | 10.1007/s00125-016-4181-3 |
| Pubmed ID | |
| Authors |
John D. Douglass, Mauricio D. Dorfman, Joshua P. Thaler |
| Abstract |
Body weight stability requires homeostatic regulation to balance energy intake and energy expenditure. Research on this system and how it is affected by obesity has largely focused on the role of hypothalamic neurons as integrators of information about long-term fuel storage, short-term nutrient availability and metabolic demand. Recent studies have uncovered glial cells as additional contributors to energy balance regulation and obesity pathogenesis. Beginning with early work on leptin signalling in astrocytes, this area of research rapidly emerged after the discovery of hypothalamic inflammation and gliosis in obese rodents and humans. Current studies have revealed the involvement of a wide variety of glial cell types in the modulation of neuronal activity, regulation of hormone and nutrient availability, and participation in the physiological regulation of feeding behaviour. In addition, one glial type, microglia, has recently been implicated in susceptibility to diet-induced obesity. Together, these exciting new findings deepen our understanding of energy homeostasis regulation and raise the possibility of identifying novel mechanisms that contribute to the pathogenesis of obesity. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 23% |
| United Kingdom | 3 | 14% |
| Germany | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Canada | 1 | 5% |
| Mexico | 1 | 5% |
| Unknown | 10 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Scientists | 6 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 155 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 19% |
| Researcher | 22 | 14% |
| Student > Bachelor | 20 | 13% |
| Student > Master | 19 | 12% |
| Student > Doctoral Student | 13 | 8% |
| Other | 21 | 13% |
| Unknown | 32 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 42 | 27% |
| Agricultural and Biological Sciences | 27 | 17% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Medicine and Dentistry | 14 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 14 | 9% |
| Unknown | 36 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#2,349,670
of 22,925,760 outputs
Outputs from Diabetologia
#1,223
of 5,056 outputs
Outputs of similar age
#49,604
of 421,168 outputs
Outputs of similar age from Diabetologia
#31
of 65 outputs
Altmetric has tracked 22,925,760 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,056 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,168 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.