Title |
Development of sarcoidosis following etanercept treatment: a report of three cases
|
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Published in |
Rheumatology International, January 2010
|
DOI | 10.1007/s00296-009-1349-x |
Pubmed ID | |
Authors |
Inger Marie Skoie, Klaus Wildhagen, Roald Omdal |
Abstract |
After over 10 years of use of tumor necrosis factor-alpha (TNF-α) inhibitors, their side effects and complications are reasonably well documented. Recently, however, granulomatous reactions and cases of complete sarcoidosis have been reported, especially in patients treated with the TNF-α receptor protein, etanercept. This is intriguing because the TNF-α antibody drugs infliximab and adalimumab are reportedly used to treat sarcoidosis. We present three patients who developed sarcoidosis while on etanercept treatment, and discuss if possible differences in cytokine profiles and T regulatory cell function in patients taking different TNF-α inhibitors may explain this paradox. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 29% |
Other | 3 | 21% |
Student > Master | 2 | 14% |
Student > Bachelor | 1 | 7% |
Lecturer | 1 | 7% |
Other | 2 | 14% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 79% |
Agricultural and Biological Sciences | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Unknown | 1 | 7% |