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Genome-wide Scan of IQ Finds Significant Linkage to a Quantitative Trait Locus on 2q

Overview of attention for article published in Behavior Genetics, December 2005
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Title
Genome-wide Scan of IQ Finds Significant Linkage to a Quantitative Trait Locus on 2q
Published in
Behavior Genetics, December 2005
DOI 10.1007/s10519-005-9003-1
Pubmed ID
Authors

M. Luciano, M. J. Wright, D. L. Duffy, M. A. Wainwright, G. Zhu, D. M. Evans, G. M. Geffen, G. W. Montgomery, N. G. Martin

Abstract

A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2-5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score>2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Germany 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Master 9 18%
Professor 4 8%
Student > Ph. D. Student 4 8%
Student > Bachelor 3 6%
Other 11 22%
Unknown 10 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 29%
Psychology 10 20%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 3 6%
Linguistics 2 4%
Other 8 16%
Unknown 9 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2007.
All research outputs
#7,428,992
of 22,711,645 outputs
Outputs from Behavior Genetics
#367
of 908 outputs
Outputs of similar age
#38,510
of 148,639 outputs
Outputs of similar age from Behavior Genetics
#5
of 13 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 908 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.