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Cortisol levels in hair are altered in irritable bowel syndrome - A case control study in primary care

Overview of attention for article published in Journal of Psychosomatic Research, December 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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51 Mendeley
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Title
Cortisol levels in hair are altered in irritable bowel syndrome - A case control study in primary care
Published in
Journal of Psychosomatic Research, December 2016
DOI 10.1016/j.jpsychores.2016.12.009
Pubmed ID
Authors

A.-K. Norlin, S. Walter, E. Theodorsson, V. Tegelstrom, E. Grodzinsky, M.P. Jones, Å. Faresjö

Abstract

Stress is an important component in the pathophysiology of irritable bowel syndrome (IBS). Long term Hypothalamus Pituitary Adrenal (HPA)-axis activity can be studied by measuring hair cortisol concentrations (HCC). Some previous studies have indicated a dysregulated HPA-axis in IBS patients, but cortisol levels in hair have not yet been studied. We investigated whether HCC and self-reported stress differentiate IBS patients from controls. In a cross-sectional study within 10 Swedish Primary Health Care Centers we compared patients in working age with active IBS to patients without GI complaints. The participants donated hair samples and completed questionnaires including a scale of self-reported perceived stress (PSS). 169 Rome III-fulfilling IBS patients and 316 non-IBS patients were available for final analyses. IBS patients had significantly lower HCC, median=16.3pg/mg, IQR=26.9pg/mg, compared to non-IBS patients, median=22.8pg/mg, IQR=29.1pg/mg. There was also a difference in the distribution of HCC quintiles between the two groups, with 30.2% IBS patients and 14.2% of non-IBS patients in the lowest quintile of HCC. PSS was higher among IBS patients with a mean (SD) total score of 25.3 (8.0) compared to controls 21.4, (7.5). Quintiles of HCC and PSS stayed significantly but very weakly related to IBS (B=-0.332, Std error=0.146, p<0.005) in multivariable analyses. This study suggests a possible suppression of the HPA-axis activity in a considerable portion of IBS patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 27%
Student > Ph. D. Student 8 16%
Student > Postgraduate 6 12%
Researcher 4 8%
Student > Master 4 8%
Other 6 12%
Unknown 9 18%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Nursing and Health Professions 7 14%
Psychology 6 12%
Biochemistry, Genetics and Molecular Biology 5 10%
Neuroscience 3 6%
Other 8 16%
Unknown 9 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2017.
All research outputs
#5,188,039
of 25,374,647 outputs
Outputs from Journal of Psychosomatic Research
#847
of 3,069 outputs
Outputs of similar age
#94,312
of 421,366 outputs
Outputs of similar age from Journal of Psychosomatic Research
#15
of 33 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,069 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,366 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.