| Title |
Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, May 2013
|
| DOI | 10.1007/s00210-013-0880-1 |
| Pubmed ID | |
| Authors |
Alexander F. Hagel, Christian M. Layritz, Wolfgang H. Hagel, Hans-Jürgen Hagel, Edith Hagel, Wolfgang Dauth, Jürgen Kressel, Tanja Regnet, Andreas Rosenberg, Markus F. Neurath, Gerhard J. Molderings, Martin Raithel |
| Abstract |
Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.5 g of intravenously administered ascorbic acid on serum histamine levels (as detected by ELISA) in 89 patients (19 with allergic and 70 with infectious diseases). When all patients were grouped together, there was a significant decline in histamine concentration from 0.83 to 0.57 ng/ml×m2 body surface area (BSA, p<0.0001). The decrease in serum histamine concentration in patients with allergic diseases (1.36 to 0.69 ng/ml×m2 BSA, p=0.0007) was greater than that in patients with infectious diseases (0.73 to 0.56 ng/ml×m2 BSA, p=0.01). Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration. Intravenous infusion of ascorbic acid clearly reduced histamine concentrations in serum, and may represent a therapeutic option in patients presenting with symptoms and diseases associated with pathologically increased histamine concentration. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 8 | 23% |
| United States | 3 | 9% |
| France | 2 | 6% |
| Canada | 1 | 3% |
| Austria | 1 | 3% |
| United Kingdom | 1 | 3% |
| Mexico | 1 | 3% |
| Unknown | 18 | 51% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 86% |
| Practitioners (doctors, other healthcare professionals) | 4 | 11% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Cameroon | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 94 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 16% |
| Student > Master | 15 | 15% |
| Other | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Researcher | 7 | 7% |
| Other | 18 | 18% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 27% |
| Agricultural and Biological Sciences | 15 | 15% |
| Nursing and Health Professions | 11 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 29 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2023.
All research outputs
#1,109,800
of 25,724,500 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#13
of 1,909 outputs
Outputs of similar age
#8,392
of 206,330 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#2
of 11 outputs
Altmetric has tracked 25,724,500 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,909 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,330 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.