| Title |
Asthma and the microbiome: defining the critical window in early life
|
|---|---|
| Published in |
Allergy, Asthma & Clinical Immunology, January 2017
|
| DOI | 10.1186/s13223-016-0173-6 |
| Pubmed ID | |
| Authors |
Leah T. Stiemsma, Stuart E. Turvey |
| Abstract |
Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes that changing environmental exposures play a significant role in the etiology of this disease. The microflora hypothesis suggests that early life exposures are disrupting the composition of the microbiota and consequently, promoting immune dysregulation in the form of hypersensitivity disorders. Animal model research supports a role of the microbiota in asthma and atopic disease development. Further, these model systems have identified an early life critical window, during which gut microbial dysbiosis is most influential in promoting hypersensitivity disorders. Until recently this critical window had not been characterized in humans, but now studies suggest that the ideal time to use microbes as preventative treatments or diagnostics for asthma in humans is within the first 100 days of life. This review outlines the major mouse-model and human studies leading to characterization of the early life critical window, emphasizing studies analyzing the intestinal and airway microbiotas in asthma and atopic disease. This research has promising future implications regarding childhood immune health, as ultimately it may be possible to therapeutically administer specific microbes in early life to prevent the development of asthma in children. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 15% |
| United Kingdom | 4 | 12% |
| Australia | 4 | 12% |
| Canada | 3 | 9% |
| India | 1 | 3% |
| Singapore | 1 | 3% |
| Austria | 1 | 3% |
| Colombia | 1 | 3% |
| Netherlands | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 64% |
| Scientists | 9 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 261 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 17% |
| Student > Ph. D. Student | 40 | 15% |
| Researcher | 29 | 11% |
| Student > Master | 27 | 10% |
| Student > Doctoral Student | 19 | 7% |
| Other | 38 | 15% |
| Unknown | 63 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 51 | 20% |
| Agricultural and Biological Sciences | 33 | 13% |
| Biochemistry, Genetics and Molecular Biology | 29 | 11% |
| Immunology and Microbiology | 29 | 11% |
| Nursing and Health Professions | 9 | 3% |
| Other | 38 | 15% |
| Unknown | 72 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2021.
All research outputs
#534,545
of 25,371,288 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#24
of 924 outputs
Outputs of similar age
#11,304
of 421,515 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#3
of 16 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 924 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,515 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.