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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Wolbachia uses a host microRNA to regulate transcripts of a methyltransferase, contributing to dengue virus inhibition in Aedes aegypti
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, June 2013
|
| DOI | 10.1073/pnas.1303603110 |
| Pubmed ID | |
| Authors |
Guangmei Zhang, Mazhar Hussain, Scott L. O’Neill, Sassan Asgari |
| Abstract |
The endosymbiont Wolbachia is common among insects and known for the reproductive manipulations it exerts on hosts as well as inhibition of virus replication in their hosts. Recently, we showed that Wolbachia uses host microRNAs to manipulate host gene expression for its efficient maintenance in the dengue mosquito vector, Aedes aegypti. Cytosine methylation is mediated by a group of proteins called DNA (cytosine-5) methyltransferases, which are structurally and functionally conserved from prokaryotes to eukaryotes. The biological functions of cytosine methylation include host defense, genome stability, gene regulation, developmental promotion of organs, and lifespan regulation. Ae. aegypti has only one DNA methyltransferase gene (AaDnmt2) belonging to the cytosine methyltransferase family 2, which is the most deeply conserved and widely distributed gene among metazoans. Here, we show that in mosquitoes the introduced endosymbiont, Wolbachia, significantly suppresses expression of AaDnmt2, but dengue virus induces expression of AaDnmt2. Interestingly, we found that aae-miR-2940 microRNA, which is exclusively expressed in Wolbachia-infected mosquitoes, down-regulates the expression of AaDnmt2. Reversely, overexpression of AaDnmt2 in mosquito cells led to inhibition of Wolbachia replication, but significantly promoted replication of dengue virus, suggesting a causal link between this Wolbachia manipulation and the blocking of dengue replication in Wolbachia-infected mosquitoes. In addition, our findings provide an explanation for hypomethylation of the genome in Wolbachia-infected Ae. aegypti. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| United Kingdom | 1 | 10% |
| Ukraine | 1 | 10% |
| Australia | 1 | 10% |
| France | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 50% |
| Members of the public | 4 | 40% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| United States | 2 | <1% |
| Brazil | 2 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Portugal | 1 | <1% |
| Venezuela, Bolivarian Republic of | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 246 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 24% |
| Researcher | 60 | 23% |
| Student > Bachelor | 28 | 11% |
| Student > Master | 27 | 10% |
| Professor | 14 | 5% |
| Other | 32 | 12% |
| Unknown | 36 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 40% |
| Biochemistry, Genetics and Molecular Biology | 68 | 26% |
| Immunology and Microbiology | 12 | 5% |
| Medicine and Dentistry | 10 | 4% |
| Environmental Science | 6 | 2% |
| Other | 17 | 7% |
| Unknown | 43 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2019.
All research outputs
#1,834,351
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#23,242
of 101,438 outputs
Outputs of similar age
#15,205
of 199,708 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#333
of 979 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,708 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 979 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.