| Title |
Neuron-Specific Expression of Tomosyn1 in the Mouse Hippocampal Dentate Gyrus Impairs Spatial Learning and Memory
|
|---|---|
| Published in |
NeuroMolecular Medicine, March 2013
|
| DOI | 10.1007/s12017-013-8223-4 |
| Pubmed ID | |
| Authors |
Boaz Barak, Eitan Okun, Yoav Ben-Simon, Ayal Lavi, Ronit Shapira, Ravit Madar, Yue Wang, Eric Norman, Anton Sheinin, Mario A. Pita, Ofer Yizhar, Mohamed R. Mughal, Edward Stuenkel, Henriette van Praag, Mark P. Mattson, Uri Ashery |
| Abstract |
Tomosyn, a syntaxin-binding protein, is known to inhibit vesicle priming and synaptic transmission via interference with the formation of SNARE complexes. Using a lentiviral vector, we specifically overexpressed tomosyn1 in hippocampal dentate gyrus neurons in adult mice. Mice were then subjected to spatial learning and memory tasks and electrophysiological measurements from hippocampal slices. Tomosyn1-overexpression significantly impaired hippocampus-dependent spatial memory while tested in the Morris water maze. Further, tomosyn1-overexpressing mice utilize swimming strategies of lesser cognitive ability in the Morris water maze compared with control mice. Electrophysiological measurements at mossy fiber-CA3 synapses revealed impaired paired-pulse facilitation in the mossy fiber of tomosyn1-overexpressing mice. This study provides evidence for novel roles for tomosyn1 in hippocampus-dependent spatial learning and memory, potentially via decreased synaptic transmission in mossy fiber-CA3 synapses. Moreover, it provides new insight regarding the role of the hippocampal dentate gyrus and mossy fiber-CA3 synapses in swimming strategy preference, and in learning and memory. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 2% |
| Israel | 1 | 2% |
| United Kingdom | 1 | 2% |
| Canada | 1 | 2% |
| Spain | 1 | 2% |
| Unknown | 50 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 16% |
| Researcher | 8 | 15% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 5 | 9% |
| Professor | 5 | 9% |
| Other | 11 | 20% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 36% |
| Agricultural and Biological Sciences | 9 | 16% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Medicine and Dentistry | 4 | 7% |
| Sports and Recreations | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 15 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2013.
All research outputs
#2,232,964
of 22,711,645 outputs
Outputs from NeuroMolecular Medicine
#33
of 446 outputs
Outputs of similar age
#19,455
of 197,453 outputs
Outputs of similar age from NeuroMolecular Medicine
#2
of 8 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 446 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.